Is this opportunity worth a deeper look?
Evaluate an inbound deck or asset against your therapeutic focus, investment criteria, and the competitive field.
Initial screen
Pressure test your investment thesis.
Investigate opportunities and keep selected diligence files current as clinical, competitive, and access developments challenge your thesis.
Investment thesis · DAPA-MI
EU trial register · Results and amendment history
Does DAPA-MI still test the outcome in our thesis?
The primary endpoint changed to a seven-component cardiometabolic composite. The original cardiovascular endpoint became secondary.
View source 23 February 2023 amendmentRevise the assumption and retain the evidence
Real source evidence.
Illustrative team files and assessments.
3 files updated
investment_committee.pptxUpdated
clinical_diligence.xlsxUpdated
DAPA-MI · Trial design
| Row | A | B |
|---|---|---|
| 1 | Protocol item | DAPA-MI |
| 2 | Primary endpoint | CV death or HF hospitalization7-component cardiometabolic composite¹ |
| 3 | CV composite hierarchy | PrimarySecondary¹ |
| 4 | Analysis to request | Component-level results |
Trial designSources
diligence_memo.docxUpdated
Clinical diligence
DAPA-MI · Protocol amendment
Thesis assumption under review
The primary endpoint directly tests cardiovascular death or HF hospitalization.The primary endpoint combines metabolic and cardiovascular outcomes. The CV death/HF hospitalization endpoint is secondary.¹
Open diligence questionHow much of a positive composite result would be driven by cardiovascular events?
¹ Source linked1
Research opportunities from the initial screen through portfolio monitoring.
What does the underlying evidence support?
Examine trial design, populations, endpoints, and access assumptions. Make the unresolved questions explicit.
Diligence memo
Which companies fit our thesis?
Map relevant companies and assets, prioritize the roster, and prepare briefs for the conversations ahead.
Meeting shortlist
What would make us revisit the assessment?
Follow clinical evidence, competitors, access decisions, financing, and transactions against your standing view.
Thesis watch
Decide what would change your view.
A thesis rests on a few assumptions. Name them, and Maven follows the evidence that bears on each one.
Clinical evidence
New trial results, publications, and regulatory updates for the asset and its class.
Competitors
Programs that enter, advance, or drop out of the field you are underwriting.
Access decisions
HTA guidance and funding criteria in the markets your forecast depends on.
Financing and transactions
Rounds, licensing deals, and acquisitions involving the company or its comparables.
Each signal arrives with its source and why it matters to your watch.
Carry the evidence from first look to committee.
01
Screen
Your team brings
Your thesis & opportunity roster
Assess fit against your criteria and the relevant company and asset landscape.
A researched shortlist02
Investigate
Company materials & diligence questions
Trace claims to publications, trials, product information, and market evidence.
A comparison you can inspect03
Challenge
Key assumptions & open questions
Check quoted support and separate reported findings from the investment interpretation.
An explicit evidence gap list04
Prepare
Your committee memo template
Build a cited assessment and supporting files in your firm’s format.
Committee materialsLive intelligence throughout the work
Product & company sitesHTA & accessLiterature & congressesTrade press & advocacyTrials, filings & deals
Keep testing the thesis as the evidence changes.
- Define what matters
- Specify the assets, companies, markets, and thesis questions to follow, including the evidence still missing.
- Understand the implication
- Receive signals with the source and the relevance to your watch. Carry material findings back into the assessment.
- Maintain your research and working files
- Upload or create files in a Maven project, then select the files to maintain. Review sourced edits, roll back changes, and download the current version.
The questions behind the thesis
01
What would substantiate the clinical claim?
02
Which competitor evidence changes the thesis?
03
Do access or partnering terms change the opportunity?
Does DAPA-MI still test the outcome in our thesis?
The primary endpoint changed. Reassess the cardiovascular thesis against the original outcome, now a secondary endpoint.
Wclinical_diligence.docx Updated
DAPA-MI · CLINICAL THESIS01
Endpoint assumptions
Maven · 1 sourced edit
The primary endpoint directly tests cardiovascular death or HF hospitalization.The primary endpoint is a 7-component cardiometabolic composite. Assess the cardiovascular thesis against the separate CV death or HF hospitalization endpoint, now secondary.1Evidence stays attached to the edit
¹ EU trial register · DAPA-MIProtocol amendment · 23 Feb 2023
The registry records a February 2023 amendment prompted by a lower-than-expected blinded event rate. The primary endpoint became a hierarchical cardiometabolic composite assessed using a win-ratio analysis. The original cardiovascular endpoint became secondary. The registry results were published on 7 July 2024.
EU trial register · Amendment 23 Feb 2023Use the intelligence inside your own stack.
Connect supported assistants through MCP, or pull monitoring findings into internal tools with the API and webhooks.
Explore integrationsKeep diligence confidential.
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Can we start with a company deck or inbound opportunity?
Yes. Add the materials and your screening criteria. Maven can research the asset, company, clinical evidence, and competitive context, then produce an initial assessment and questions for deeper diligence.
Can the monitor follow our thesis rather than a news category?
Yes. Define the entities, markets, and questions that matter to the assessment. Maven evaluates incoming evidence for relevance to that scope, sends monitoring signals, and can update selected documents with sourced edits and rollback.
We already use AI internally. Can Maven supply the intelligence?
Yes. Connect supported assistants through MCP, or use the API and monitoring webhooks in your own tools. The Maven Bio connector is listed in Claude’s directory. Your team can combine that intelligence with its internal context and research methods.